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DTSTART;TZID=Europe/London:20260113T133000
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DTSTAMP:20260404T092215
CREATED:20250922T131905Z
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UID:10000126-1768311000-1768321800@skillsacademy.newcastle-hospitals.nhs.uk
SUMMARY:Targeted treatments and immunotherapy for Bowel Cancer
DESCRIPTION:Delivered over one afternoon session\, Dr Elaine Vickers – a leading independent educator on the science of new cancer treatments – provides an up-to-date overview of modern systemic treatment approaches given to people with bowel cancer including treatment combinations and new approaches currently being investigated in clinical trials. \nElaine first of all looks at the gene mutations and faulty processes and pathways that give rise to bowel cancer\, explaining the relationship between mismatch repair deficiency (dMMR) and microsatellite instability (MSI). \nShe then turns her attention to antibodies that target the EGF receptor (EGFR) and also summarises why they’re only effective for some people and looks at various reasons for resistance. \nCheckpoint inhibitor therapy has recently given highly promising results in trials\, but only if the tumour is dMMR/MSI. Elaine will describe why this is\, and explore whether immunotherapy might still hold promise for people whose cancers don’t display this characteristic. \nLastly\, Elaine will look at other targeted therapies and immunotherapies that have shown recent promise in trials. These include drugs that target B-Raf\, HER2 and Ras proteins. \nAudience\nDr Vickers’ goal is to explain the science that underpins each treatment. She also hopes to provide learners with a broad understanding of why treatments work well for some patients but not for others. \nThis half day course is ideal for research nurses\, clinical nurse specialists\, pharmacists and clinical trials coordinators. It may also be of interest to other healthcare professionals involved in the diagnosis and treatment of people with bowel cancer\, and to junior doctors. \nACCEND\nNHS England’s ACCEND Programme aims to support the development of a skilled and knowledgeable cancer workforce. \nThis course supports Component 3 of the ACCEND pathway\, the Education Framework. \nSpecifically\, this course’s objectives and learning outcomes meet core cancer knowledge needs at both the ‘Foundation of Cancer Care’ and ‘Fundamentals of Cancer Care’ levels. \nThe course will enhance learners’ understanding of cancer biology\, the mechanism of action of systemic cancer treatments\, and the use of biomarkers to select the best treatments for each patient. \nThe knowledge gained through this course will empower staff to feel confident when communicating with patients and their families\, and with clinical and non-clinical colleagues. \nDetailed description\nPresentation 1 – Biology and genetics of bowel cancer \n\nCell of origin and mechanisms of development\nThe tumour microenvironment\nKey mutations and defective pathways and proteins in bowel cancer cells\nExplaining the relationship between mismatch repair deficiency (MMRd)\, microsatellite instability (MSI) and CPG-island methylator phenotype (CIMP)\n\nPresentation 2 – Targeting the EGFR in bowel cancer \n\nHow cells communicate using growth factor receptor-controlled signalling pathways\nThe normal function of EGFR (epidermal growth factor receptor)\nMechanisms of action of EGFR-targeted antibodies\nWho benefits from EGFR-targeted antibodies?\nKRAS mutation testing and left sided vs. right sided bowel cancers\nShould we be doing more testing?\n\nPresentation 3 – More targets and treatments for bowel cancer \n\nAngiogenesis inhibitors\nImmunotherapy for people with MMR-deficient/MSI bowel cancer\nImmunotherapy for people with MMR-proficient bowel cancer\nB-Raf inhibitor combinations for people with BRAF-mutated tumours\nTargeting HER2\, mutant K-Ras\, and Trk proteins\n\nPre-course preparation\nElaine has created two YouTube playlists about cancer biology and cancer treatments to help learners get the most out of her courses. Each playlist contains 10 videos between 3 and 8 minutes long. \nElaine advises “If you’re short on time and you’re not sure about the relationship between DNA\, genes and proteins\, I would suggest watching the Cells\, DNA\, genes and chromosomes and From genes to proteins videos from the Cancer Basics playlist as a priority. Also\, if you’re new to cancer\, I’d recommend the Mutations cause cancer video and\, in order to understand how cancer cells interact with the cells around them\, watch the Tumours are complicated places video.” \n“In the Cancer Treatments playlist\, there are videos about all the various treatments I’ll be mentioning. The two I’d prioritise explain why we use small chemical compounds (small molecules) and antibodies as cancer treatments. If you have more time\, do also watch the videos on kinase inhibitors and immune checkpoint inhibitors.” \nAbout Elaine Vickers\nDr Elaine Vickers\nElaine Vickers of Science Communicated Ltd has a PhD in Molecular Biology. She has worked as a cancer educator for over twenty years. \nShe is passionate about demystifying the science behind cancer biology and the latest cancer treatments such as kinase inhibitors\, monoclonal antibodies\, and immunotherapies. \nElaine is experienced in teaching people with any level of scientific or medical knowledge. She particularly loves teaching nurses and other health professionals who might feel daunted by the idea of learning about cancer science. \nHer book\, A Beginner’s Guide to Targeted Cancer Treatments and Cancer Immunotherapy\, is now in its second edition. The first edition was Highly Commended by the British Medical Association book awards. \nElaine also makes short educational videos on cancer biology and treatments\, which you can find on her YouTube channel: https://www.youtube.com/@DrElaineVickers
URL:https://skillsacademy.newcastle-hospitals.nhs.uk/course/targeted_treatments_immunotherapy_bowel_cancer/
LOCATION:Virtual delivery via MS Teams
CATEGORIES:Cancer courses
ATTACH;FMTTYPE=image/jpeg:https://skillsacademy.newcastle-hospitals.nhs.uk/wp-content/uploads/2025/09/Bowel-Cancer.jpg
ORGANIZER;CN="Newcastle Hospitals Skills Academy":MAILTO:nuth.newcastlehospitalsskillsacademy@nhs.net
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